That should be quite easy, certainly if you do it manually, with the champions you have... Scyl, Sethallia, Doompriest, Tayrel and whoever you like as fifth. Make sure Sethallia has her AOE buff strip ready whenever the spiderlings spawn with their counterattack buffs, so she can immediately strip that and Tayrel / any other AOE hitters can do their job. Scyl, Sethallia and Doompriest will heal and cleanse the poisons. 

Do  you  have  Spirit  Affinity  or  Force  Affinity  Poison  Hero  or  HP  Burn  Hero?

Yes, Salia has HP burn

Sethalia

Thanks L9753, used that team manually and tore it up.