Honestly - I wouldn't even bother until you have champs that are either: A) strong enough to 3* the entire Nightmare campaign (perhaps with the exception of 12-7, since that fight is just stupid), or B) strong enough to solo farm 12-3/12-6.
For that particular fight, you shouldn't really have any major troubles - just run two red champs, ideally either both running lifesteal or with one as a healer. If you post your roster I can see which would be ideal