Thanks Rat.

But since its actually a good question.

1.  IMO always go for the sustain options.  Very very very rarely have I lost a fight because of lack of damage, you will lose cuz youre too slow and squishy.

2.  Location of champs in the deck is irrelevant.  However im a big fan of one deck all damage champs and the other all support so you get a good mix.

Yeah, early on i prioritize resist and def

I can agree with your second point. It's didn't matter when it came to normal but hard was where I stumbled. When you get a hard fight, it's really hard to get a healer at times when you only get 10 picks from the 40. I thought that by spreading them all over both teams I would get 50:50 odds but when 3/4 of your team is unavailable, that's where the math statistics came into play. I also had issues with heal reduction for mimics in hard. I plan of putting 6 or 7 on the one team so that I don't have to keep losing my rerolls for them.