Well the philosophy about pop-up warnings is quite researched. Dont display them too often because the users start to ignore them.
About exactly which champions they should warn about is ofcourse debatable. Do you want to annoy all players that have played for more than 4 months and dont want relic keeper and broadmaw forever, in order to please f2p that have played less than 4 months?
I would be surprised if it is the latter for two reasons. Firstly you annoy what i am guessing is 95% of the playerbase. Secondly you annoy the part of the playerbase that influence your income.
Remember players still have the option to lock champions they dont want to sacrifice. There are other solutions besides my suggestion.
It could also be something you tick off- on the fusion itself. Tick here if you are interested in this fusion and want warnings when sacrificing required champions? would be fine for me. I would even be fine with it being a generel setting. Do you want fusion sacrifce warnings?
For me it would be a sure no with the current implementation.
I will be honest. I thought it was a good idea when I first read about and it probaly still is. I think it is an awful implementation after experiencing it. Just think of all those diabolist warnings we are going to get. I sure hope there wont come a fusion that includes incubus.