Great news! You've got two Champions that I'm currently using as my Go First team and it should be 70% or higher win rate with your champions.
1. Lyssandra and Wukong. Put Wukong in Lead, give Lyssandra the highest speed possible while keeping Acc at atleast 250 and Wukong at about 300 or more Acc. You're really gonna want to get Lyssandra's speed above 300 to be able to do the most battles per Refresh. If Lyssandra doesn't go first, you've got a low chance of winning.
2. You need 2 more champions from you pool that are AOE Nukers. If its just a single AOE they have but it hits hard, use them.
3. Lyssandra will go first, Wukong must go 2nd before your other two AOE Nukers. All 4 should be able to go before the enemy gets a single turn. This is pretty easy with Lyssandra's A3 doing the Turn Meter swing
4. So here's how it plays out: Lyssandra does A3, then Wukong goes. Wukong strips all their non-protected buffs and places Block Buffs. It would be best to have the Champion going 3rd to do AOE Decrease Defense or Weaken on their Nuke so if they survive, your 4th Nuker will have a better chance of finishing them. Wukong will strip Stoneskin (if not protected) and the way the mechanics work, if they have Leorius or Skullcrown, the Block Buffs will block their Unkillable Passive and they will die when they take a fatal hit.
5. Ok so here's what you need to avoid and what will mess your team up: Hegemon (Avoid any team with him) and super high resist Pythion/Duchess. Protected Stoneskin is a RNG situation but if you see a Pythion or Duchess on their team, assume it has a full set on. Also if they have a speed lead and their Arbiter or Lyssandra ect goes first, you're probably going to die.
Your entire goal is to kill the whole team and not have a reviver left to bring them back. Mithrala isn't a problem with her super high resist, because she can't revive. UDK isn't a problem because Wukong can sheep him.
Final Note: If you get lucky and pull Gnishrak from a Shard, you'll have a much higher win rate, even with the Stoneskin Pythion. In fact, you'll practically WANT him to have a Protected Stoneskin so Gnish's bombs absolutely wreck him on his first turn when he's the only one left standing.