It has been talked about, but working in concert with Duchess seems sweet. Something like...
Pythion fastest/Duchess or another damage mitigation champion/Ukko/Insert nuker like Candraphon, Mortu, cheaty void nuker if you're blessed in obvious sets is real, real fun on defense. That's one route I plan on exploring, but I really think Pythion is absurd.
There's just some very, very annoying options on defense here, and then making adjustments on offense.
Okay - so in said team, the main value Pythion is bringing is the debuff removal + block debuffs, alongside a revive?
I'd daresay on that same team, that Raglin would do a better job. Same for Elva. Siphi I think goes without saying as being a better choice here too.
Now, of course, I am obviously being pretty selective with who I'm naming, and not everyone will have those people. I suppose I'm mostly talking from my own perspective, given that I already have a pretty deep selection of these types of champs, between Raglin, Wythir, and Mithrala.